Resveratrol, a natural compound for memory, learning and cognitive functions.✝
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Resveratrol (3,5,40-trihydroxystilbene) is a biologically active polyphenolic compound found in grapes, red wine, some berries, dark chocolate and peanuts.1 Resveratrol is also sold as a nutritional supplement.
Resveratrol has been studied and demonstrated to be a multipurpose compound with antioxidant, anti-inflammatory, anti-angiogenic, neuroprotective and cognition-enhancing effects.3 As such, it is used in the treatment of various age-related disorders, such as Alzheimer’s disease (AD) and other neurodegenerative diseases.1 For example, a recent study suggested that therapeutic use of resveratrol may help delay the onset of AD or slow down its progression.3 Resveratrol has been even called the “elixir” of youth that can potentially increase the human lifespan and improve general health in humans.6
In addition, resveratrol and its cardioprotective effects are often mentioned in the so-called “French Paradox” which is a term coined to describe a lower rate of cardiovascular diseases in French people.2 One of the early theories has linked the “French Paradox” with the relatively high consumption of red wine, which contains resveratrol, in France.
In terms of resveratrol nootropic effects, a randomised, double-blind, placebo-controlled study in young, health humans demonstrated that its chronic consumption over 28 days increases the cerebral blood flow (CBF) with a less clear effect on cognitive tasks.4
Overall, resveratrol is a nutraceutical with some very promising effects as a nootropic. In addition it is a supplement with many health benefits, such as fighting disease, preventing cancer and slowing aging.
The daily recommended dosage of resveratrol is between 250 and 750 mg. Interestingly, previous studies on resveratrol have used a very wide range of dosages (from 25 mg to 5 g) in either single or multiple administrations with no reported major side effects.7 However, dosages as high as 5 g/day are not recommended. Although, some studies show positive biological responses following a single dose of resveratrol, a longer supplementation may be required for greater effects.6
Resveratrol has a relatively low bioavailability, which is also reported in other polyphenols.6 However, resveratrol bioavailability can be improved by co-supplementing it with piperine (pepper-derived alkaloid).5 Previous studies used 250 mg of resveratrol plus 20 mg of piperine.5
Resveratrol is an anti-oxidant and a polyphenol that interacts with many different receptors, kinases, and other enzymes.6
Resveratrol is a safe and generally well-tolerated supplement.
Serving size: 1 capsule
Servings per bottle: 120
Amount per serving: Resveratrol 250mg
This product is free from: Artificial Flavours, Colours & Preservatives, Lactose, Yeast & Gluten
Suitable for: Vegetarians and Vegans
✝ These statements have not been evaluated by the Food and Drug Administration (FDA) The above products are not intended to diagnose, treat, cure or prevent any disease. You should consult a physician before taking a new product or a nootropic. This product should not be taken by pregnant or nursing mothers, people suffering from cardiovascular disease or those under 18 years of age.
Any studies cited here are not conclusive and are limited to their closed environment nature; they might not determine ones experience with a nootropic, due to a large number of unaccounted variables falling outside the scope of such studies.
The reviews available here are the opinions of contributors who may or may have not used these products, and do not necessarily represent the views of ThoughtFoods. These reviews represent one’s opinion and should not be taken as fact or recommendation. ThoughtFoods makes no warranty to the accuracy of information provided by these reviews.
2. Catalgol, B. et al. (2012). Resveratrol: French paradox revisited, Front Pharmacol. 3: 141.
3. Venigalla, M. et al. (2015). Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer’s disease, Neurochem Int. [Epub ahead of print].
4. Wightman, E.L. et al. (2015). The effects of chronic trans-resveratrol supplementation on aspects of cognitive function, mood, sleep, health and cerebral blood flow in healthy, young humans, Br J Nutr. 114 (9): 1427-37.
5. Wightman, E.L. et al. (2014). Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation, Br J Nutr. 112 (2): 203-13.
6. Smoliga, J.M. et al. (2011). Resveratrol and health – a comprehensive review of human clinical trials, Mol Nutr Food Res. 55 (8), 1129-41.
7. Bigford, G.E. & Del Rossi, G. (2014). Supplemental substances derived from foods as adjunctive therapeutic agents for treatment of neurodegenerative diseases and disorders, Adv Nutr. 5 (4), 394-403.
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