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CDP-choline (aka Citicoline) is a nootropic that has been significantly growing in popularity in recent times. This may be explained by its multipurpose use. Firstly, CDP-choline is capable of improving a number of cognitive functions, including memory, learning ability, concentration and speed of thought processing. Secondly, Citicoline is very effective in protecting the brain from damage and keeping it healthy over long-term. As a neuroprotective agent it is used in the treatment of neurological disorders, such as dementia, Parkinson’s disease and stroke. Finally, CDP-choline has been successfully used to treat different types of addictions as it has been shown to have positive effects on craving and withdrawal symptoms.
Because of its wide-ranging effects, this product is considered to be one of the best nootropics, especially for beginners. CDP-choline also helps to diminish the headaches often caused by racetam nootropics. In fact, it works synergistically with other nootropics, which means that CDP-choline may drastically boost the positive effects of other nootropics. That is why it is a popular nootropic supplement in many stacks.
In terms of its mechanistic functions, it is very important for the biosynthesis of membrane phospholipids. In addition, CDP-choline increases the levels of acetylcholine, norepinephrine, dopamine, serotonin and tyrosine. Citicoline is a precursor of the acetylcholine neurotransmitter. This makes CDP-choline one of the most choline sources among nootropics users. Other two nootropic compounds are Alpha GPC and Phosphatidylcholine (PC). However, CDP-choline is more effective than PC and demonstrates a similar effectiveness compared to Alpha GPC.
The recommended daily dosage of CDP-choline is between 500-2000 mg. For maximal results it should be taken in two equal administrations separated by 8-12 hours. Current evidence suggests that dosages higher than 2000 mg do not provide any additional effects.
As mentioned before, CDP-choline consists of two essential components - choline and cytidine diphosphate. Upon ingestion CDP-choline is therefore converted to its two main components - choline and cytidine. The latter is then converted to uridine.
Choline is one the most important nutrients for the brain. It is used by the cells in the synthesis of Acetylcholine, an essential neurotransmitter responsible for synaptic plasticity. This way CDP-choline is able to assist in developing better memory formation, learning capacity, focus, concentration, problem solving and decision making. Because this product is such a good source of choline, it is often stacked with other nootropics like Aniracetam, Oxiracetam or Noopept. A combination like this has great synergistic capability, allowing the body to make the most of the increased levels of acetylcholine activity in the neurons.
Cytidine Diphosphate is sometimes considered as a secondary component of the product, but it is actually no less important. It is responsible for the maintenance and repair of the brain tissue, including neurons. A major part of the cell membranes in the brain is made of it. As much as 30 percent of the grey matter tissue is actually made of Cytidine Diphosphate. Naturally, the cells and membranes slowly wear out with aging. CDP-choline has the capability to recondition them, allowing more efficient functioning and communication.
Another way CDP-choline helps the cognition is by improving the blood flow into the brain. It results in a greater oxygen uptake, while the glucose metabolism is also increased. Quite often, this effect alone leads to notable mental energy changes. Many people report the ability to concentrate deeper and for longer periods of time. Scientists are also now researching the CDP-choline as a potential treatment of ADD/ADHD in both adults and children.
Absorption rate of CDP-choline is very quick. Once it is absorbed it crosses the blood-brain barrier and reaches the central nervous system (CNS) where it increases cerebral metabolism and helps with the release of all important neurotransmitters. Its oral bioavailability is greater than 90%, which is higher than other similar products.
CDP-choline is considered to be a very safe use with a low toxicity profile. No negative effects on the cholinergic system have been reported. A large study with 2817 cases reported no side effects in 95% of patients. The remaining 5% of patients experienced digestive symptoms, such as nausea and cardiovascular symptoms, like low blood pressure.
CDP-choline is available in both, bulk powder and capsules. Although, its preferred form depends on personal factors and circumstances, advanced nootropics users like to buy CDP-choline powder. They report that it starts working faster, because of the much more rapid absorption rate into the bloodstream. Also, powder can also be dosed based on individual needs, as opposed to capsules, which are typically sized at 500 mg.
Serving size: 1000 mg
Servings per tub: 100
Amount per serving: 1000 mg CDP-choline
This product is free from: Artificial Flavours, Colours & Preservatives, Lactose, Yeast & Gluten
Suitable for: Vegetarians and Vegans
✝ These statements have not been evaluated by the Food and Drug Administration (FDA) The above products are not intended to diagnose, treat, cure or prevent any disease. You should consult a physician before taking a new product or a nootropic. This product should not be taken by pregnant or nursing mothers, people suffering from cardiovascular disease or those under 18 years of age.
Any studies cited here are not conclusive and are limited to their closed environment nature; they might not determine ones experience with a nootropic, due to a large number of unaccounted variables falling outside the scope of such studies.
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