A more potent cognitive enhancer than Aniracetam. ✝
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Nefiracetam is a nootropic compound that increases brain power by stimulating key areas of the brain. Nefiracetam is fairly new to the market and therefore is not as popular as other nootropics from the racetam family. Phase 1 study of Nefiracetam was carried out only as recently as 1994. However, Nefiracetam has been widely studied since then. This includes testing its nootropic effects as well as general safety for human consumption.
Although, it was developed from the original racetam, structurally it is more similar to Aniracetam. They both are fat soluble and have been shown to improve memory and learning capacity. Also, both of these nootropics have certain neuroprotective capabilities. Nefiracetam is one of the best nootropics if you are looking to improve your attention span, focus and concentration.
Cognitive enhancement is the main reason why people use nootropics and Nefiracetam is no exception. Cognition is made up of a number of various functions. Memory, learning capacity, logical thinking, attention, planning and impulse control, just to name a few. Racetam family nootropics are praised for improving all of these functions. Nefiracetam is particularly beneficial in long-term memory storage and information recall.
As claimed by several studies, the compound may improve one’s spatial learning capabilities. Nefiracetam is thought to be effective in treatment of patients with mental decline disorders. It has apparent abilities to maintain the health of the brain cells. Thanks to its cytoprotective actions, it is believed Nefiracetam can protect brain neurons from abnormally early cell death.
Compared to its cousin racetams, such as Pramiracetam and Oxiraceta, Nefiracetam has a much stronger effect on attention span, focus and concentration. Much like Aniracetam, it is reported to help manage stress and anxiety, while even showing promise to relieve symptoms of depression. Even though the mechanisms of action are alike in both products, Nefiracetam seems to possess a larger variety of effects. Differently to Aniracetam, it exhibits strong GABAergic and monoaminergic properties. This could explain why Nefiracetam is a much more potent anxiolytic. Research shows its effectiveness in helping patients suffering from severe clinical depression. Another study suggests that Nefiracetam may be successful in stopping or reducing various types of seizures. The claim includes both convulsive and non-convulsive ones. The nootropic primarily reduces the symptoms of amygdala based seizures. Also it may help reduce frequency and span of post-stroke seizures.
Different dosages of Nefiracetam have been used in the clinical studies. This has caused some confusion as to what the appropriate dosage levels should actually be. If you look for information online, both in product review sites, as well as nootropic discussion boards, you will find a number of various different views. A better place to look for that kind of information is the scientific literature. Currently, the recommended relative dosage is between 8 to 30 mg per kilogram of bodyweight per day. For an average person weighing 70 kg, this works out between 560 to 2100 mg per day. A wide range of dosage means that effects will be very individual. Thus, you should optimise the dosage based on your body mass as well as individual response to Nefiracetam. Start off with the lowest recommended dose and gradually increase it until you are pleased with the effects. Careful dosing approach is especially recommended with such relatively new and experimental nootropics like Nefiracetam. Another thing to keep in mind before taking the product, is that Nefiracetam is fat soluble. Ingest it with a fatty meal or simply a glass of milk. Biological half-life of Nefiracetam is 3-5 hours.
Mechanisms of actions of Nefiracetam are similar to other racetams. Firstly, it works by prolonging opening of calcium channels. Nefiracetam is capable of enhancing the signalling of a receptor independent of the synapse. Effectively this results in more stimulation in the brain and ensures that individual neurons are fired when it is required. If the calcium channels are open for longer durations, the information contained in any excitatory neurotransmitter can be amplified. This may help different areas of the brain to communicate and strengthen memory formation.
Another mechanism of action, commonly linked to Nefiracetam, is the potentiation of nicotinic acetylcholine receptors. The action results in various different effects, but most notably the release of GABA and glutamate neurotransmitters. These are some of the most potent neurotransmitters found in the brain. For example, GABA eases the brain into a state of relaxation, it stops anxiety, relieves stress and generally calms the brain down. It is the main inhibitory chemical. Whereas glutamate and acetylcholine work by helping the brain with the formation of new memories, enlarging learning capacity and many other processes. These neurochemicals are closely associated with the concept of synaptic plasticity. They actually aid in creation of new neurons and pathways inside the brain.
There is no evidence of toxicity or human risk related to Nefiracetam consumption. Human studies, however, have been scarce and the upper dosage limit has not been established as of yet. Studies showed that doses as high as 900 mg daily are safe in healthy individuals.
The typical side effects of Nefiracetam are similar to those reported following the use of other racetams. They may include headaches, nausea, irritability, fatigue, dizziness and stomach problems. Headaches are the most common problem that racetam users have to cope with, but it can be quite easily prevented. That is done by adding a source of high quality choline compound to your nootropic stack. Examples of effective choline sources are: Alpha GPC or Centrophenoxine. Other listed side effects are very rare and do occur only if excessive dosages are used.
Serving size: 1 scoop (500 mg)
Servings per tub: 200
Amount per serving: Nefiracetam 500 mg
This product is free from: Artificial Flavours, Colours & Preservatives, Lactose, Yeast & Gluten
Suitable for: Vegetarians and Vegans
✝ These statements have not been evaluated by the Food and Drug Administration (FDA) The above products are not intended to diagnose, treat, cure or prevent any disease. You should consult a physician before taking a new product or a nootropic. This product should not be taken by pregnant or nursing mothers, people suffering from cardiovascular disease or those under 18 years of age.
Any studies cited here are not conclusive and are limited to their closed environment nature; they might not determine ones experience with a nootropic, due to a large number of unaccounted variables falling outside the scope of such studies.
The reviews available here are the opinions of contributors who may or may have not used these products, and do not necessarily represent the views of ThoughtFoods. These reviews represent one’s opinion and should not be taken as fact or recommendation. ThoughtFoods makes no warranty to the accuracy of information provided by these reviews.