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Pramiracetam is currently the strongest racetam that has been synthesised from the original racetam. Pramiracetam was first developed in the late 1970s in Belgium. Over time the research on Pramiracetam continued. Structurally it has similarities with Aniracetam, however it is more potent. Therefore, it is important to take extra care when using it as lower dosages are required (see below).
Compared to some other nootropics from the racetam family, Pramiracetam works even after acute administrations. Pramiracetam provides noticeable improvements in cognition, memory and mental abilities. This is linked with its effects on acetylcholine neurotransmission in the brain. Pramiracetam benefits the long-term memory the most. A study carried out in 1991 found that Pramiracetam significantly improved memory in young people with brain injuries. More recent studies also show promising results in Pramiracetam’s abilities to treat degenerative neural conditions, such as Alzheimer’s disease.
The recommended daily dosage is 500 – 1200 mg taken in 2 or 3 equal administrations. Pramiracetam should be taken with a meal. It is not advised to exceed a 1.5 g/day dosage.
Pramiracetam appears to start working between half an hour to an hour post-ingestion and its effects usually last more than 5 hours. Biological half-life of Pramiracetam is 4-6 hours. Therefore, timing of acute administration of Pramiracetam before cognitive tasks should be planned accordingly. Due to its potency, Pramiracetam is often used by the experienced nootropics users who have tried other slightly less potent racetams (e.g. Aniracetam and Oxiracetam). Pramiracetam can also be used in a stack. User may develop tolerance after a prolonged use of high dosages. Thus, if you are regular user of Pramiracetam you should once in a while consider taking a couple of weeks off.
Even though the complete scientific understanding of Pramiracetam’s mechanisms of action is not available yet, scientists have made good advancements in this area. Pramiracetam is absorbed by intestines, where it enters the blood and is then transported to the brain. In the brain it binds to acetylcholine receptors (as do all racetam nootropics). That alone boosts memory formation and learning capabilities. Simultaneously, there is an increase in the blood flow to the brain which increases the delivery of oxygen, nutrients and vitamins. This way, additional benefits, like mental energy and increased focus as well as improvement in the general brain health are achieved. According to different studies, Pramiracetam can boost choline levels in the area of the brain called hippocampus. The hippocampus is responsible for memory and spatial navigation. Interestingly, Pramiracetam has been shown to have promising results in increasing the neural communication between the left and right hemispheres by having a positive effect on the corpus callosum.
Pramiracetam is non-toxic and very well tolerated. However, due to its potency it requires high amounts of choline to be used in a stack. Failure to do this may result in unnecessary headaches. This is the main side effect of racetams. Therefore, the solution to this problem is rather simple – you should take choline products, such as Alpha GPC, which will replenish the brain’s stores of choline and will prevent the unpleasant side effect. Other, very rare, side effects may include nausea and sleeplessness. Both of these side effects are associated with the stimulating effects of Pramiracetam.
Serving size: 400 mg
Servings per tub: 250
Amount per serving: Pramiracetam 400 mg
This product is free from: Artificial Flavours, Colours & Preservatives, Lactose, Yeast & Gluten
Suitable for: Vegetarians and Vegans
✝These statements have not been evaluated by the Food and Drug Administration (FDA) The above products are not intended to diagnose, treat, cure or prevent any disease. You should consult a physician before taking a new product or a nootropic. This product should not be taken by pregnant or nursing mothers, people suffering from cardiovascular disease or those under 18 years of age.
Any studies cited here are not conclusive and are limited to their closed environment nature; they might not determine ones experience with a nootropic, due to a large number of unaccounted variables falling outside the scope of such studies.
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