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Sunifiram (aka DM-235) is a relatively new but very promising nootropic that has been recently introduced to the market. It is an AMPA agonist and therefore belongs to the ampakine nootropic family. Structurally, Sunifiram is very similar to the original racetam, but it is much potent.
The compound has been shown to be effective in improving memory, prolonging attention span, promoting learning, better decision making and alertness. Although more research and human studies are needed, Sunifiram may very well turn out to be one of the most wanted studying and concentration aids. Not only it delivers as an effective memory enhancer, but it is also being studied for the ability to treat Alzheimer’s disease.
Users say the product primarily helps with information recall and thought clarity. Because of its high potency, Sunifiram is often compared to Noopept. Early report indicate Sunifiram having an edge at improving memory, while Noopept holds the advantage as the nootropic of choice for increased focus and alertness.
Sunifiram drastically enhances user’s energy levels and ability to concentrate on a given task. Many find that it is very useful for self-motivation to combat procrastination.
The way Sunifiram works closely resembles the nootropics from the racetam family. It stimulates most of the same receptors, but does that in a slightly different way. Sunifiram mainly stimulates AMPA receptors, which is why it is called AMPAkine. These receptors are in charge of glutamate production in the brain. When patients were given NBQX (AMPA antagonist), followed by a dose of Sunifiram, increased AMPA receptor activity was clinically observed.
Glutamate is a vitally important neurotransmitter. It communicates excitatory transmissions, forms connections between synapses and is in control of the brain cell maintenance function. Brain metabolism and synaptic plasticity are tremendously dependent on glutamate. Insufficient levels of this neurotransmitter result in impaired memory, inability to learn, lost focus and many other cognition weaknesses.
Sunifiram appears to be able to normalize glutamate levels and effectively enhance the brain performance. Users of this compound report high cognitive endurance, even after prolonged mental activity. Storing information and understanding new concepts becomes easier.
Compared to racetam nootropics, such as Pramiracetam, Aniracetam and Oxiracetam, Sunifiram is also involved in increasing the acetylcholine levels. This neurotransmitter is very important for thinking process, memory, alertness and focus. It helps the two hemispheres of the brain communicate better, which improves pattern recognition and social skills.
As mentioned before, Sunifiram is a highly concentrated substance. Therefore, 4 mg is enough to notice the positive effects, but many users take between 5-8 mg/day. Currently, it is unknown if higher dosages provide further effects. It is recommended to start by taking 4 mg dosage at the start and allow yourself to get familiar with its effects, before increasing the dosage.
Sunifiram acts similarly to Nefiracetam in the hippocampus area of the brain. It is an AMPAkine which mainly works via the AMPA receptors to provide the aforementioned effects. Specifically, it activates AMPA receptors to release glutamate neurotransmitter. Glutamate is often recognized as the most important neurotransmitter for normal brain function.
Important - Sunifiram is not for sale until there are enough human studies and clinical trials carried out and it is proven to be 100% safe.
Based on the current evidence Sunifiram has a low toxicity profile. However, some mild side effects have been reported. These include headaches, anxiety, restlessness, nausea and increased perspiration. Most of these side effects only occur when higher than recommended dosages are used.
✝ These statements have not been evaluated by the Food and Drug Administration (FDA) The above products are not intended to diagnose, treat, cure or prevent any disease. You should consult a physician before taking a new product or a nootropic. This product should not be taken by pregnant or nursing mothers, people suffering from cardiovascular disease or those under 18 years of age.
Any studies cited here are not conclusive and are limited to their closed environment nature; they might not determine ones experience with a nootropic, due to a large number of unaccounted variables falling outside the scope of such studies.
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